Differences between Salk type (IPV) and Sabin type (OPV) vaccine

July 3, 2022

The differences between Salk and Sabin type vaccine are as follows:

S.N	Salk type (IPV)	S.N	Sabin type (OPV)
1.	Stands for inactivated polio vaccine.	1.	Stands for oral polio vaccine.
2.	Virus used is killed and formalized.	2.	Virus used is live and attenuated.
3.	Administered subcutaneously or intra muscularly.	3.	Administered orally.
4.	Good systemic immunity whereas mucosal slight or moderate.	4.	Good systemic immunity whereas excellent mucosal.
5.	Reversal of virulence through mutations not known.	5.	Reversal of virulence may be possible.
6.	Enteric viruses do not interfere the efficiency of vaccine.	6.	Enteric viruses may interfere its efficiency.
7.	Vaccine associated disease complication is not known.	7.	Vaccine associated disease complication may be possible.
8.	Vaccine administration is allowed to immune-compromised host.	8.	Vaccine administration is not allowed or recommended to immune-compromised host.
9.	High in manufacturing cost.	9.	Low in manufacturing cost.
10.	Jonas Salk developed this vaccine in 1954.	10.	Albert Sabin developed this vaccine in 1961.
11.	Long term immunity provided.	11.	Longer time immunity provided than Salk.
12.	Paralysis associated with the vaccine not observed.	12.	Paralysis associated with the vaccine is observed in very few cases.
13.	Antibody developed on the body is IgG.	13.	Antibodies developed in the body are IgG and IgA.
14.	Storage and transport does not require stringent conditions. Shelf life is longer.	14.	Storage and transportation needs sub-zero temperatures, unless stabilized. Can be damaged easily.
15.	Manufacturing is difficult.	15.	Manufacturing is easy.
16.	Controlling epidemics may not be possible.	16.	Can be more effective in controlling epidemics.
17.	Mostly used in developed countries.	17.	Mostly used in developing countries.