Auto immunity: Introduction and Mechanism

Introduction A condition resulted by the action of antibodies or immunologically competent cells. Cause structural or functional damage of the normal components of the body. Literally means ‘protection against self’ but means ‘injury to self’ in actual. Ehrlich postulated the concept of horror auto-toxicus. Was proposed while observing goats producing antibodies against erythrocytes from other … Read more

Immunoglobulin M (IgM): Structure and Properties

Properties This type of immunoglobulin accounts or constitutes 5-10% of total serum immunoglobulin in adults. The serum concentration is 5-2 mg per 100 ml. The half-life of IgM is about 5 days. It can be produced in a T-independent manner. Monomeric IgM has molecular weight of 180,000 Da which is expressed as membrane bound antibody … Read more