idiotype

Auto immunity: Introduction and Mechanism

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Introduction A condition resulted by the action of antibodies or immunologically competent cells. Cause structural or functional damage of the normal components of the body. Literally means ‘protection against self’ but means ‘injury to self’ in actual. Ehrlich postulated the concept of horror auto-toxicus. Was proposed while observing goats producing antibodies against erythrocytes from other … Read more

Antigenic determinants on immunoglobulins

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Immunoglobulin molecules themselves function as potent immunogens when they are introduced into other animal species to induce an antibody response. For studying the B cell development and humoral immune response, such anti-Ig antibodies are considered to be a powerful tool. The antigenic determinants are also called epitopes on immunoglobulin molecules. They are categorized into three … Read more