myeloma

Monoclonal antibodies: Principle, Technique and Uses

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Antibodies are produced ordinarily by infection or immunization in an animal in response to a single antigen. They are heterogenous as they are synthesized by several different clones of antigens, i.e. they are polyclonal. Such antisera contain immunoglobulins of different classes with specificities against different epitopes of the antigen. Principle Monoclonal antibodies are those which … Read more

Antigenic determinants on immunoglobulins

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Immunoglobulin molecules themselves function as potent immunogens when they are introduced into other animal species to induce an antibody response. For studying the B cell development and humoral immune response, such anti-Ig antibodies are considered to be a powerful tool. The antigenic determinants are also called epitopes on immunoglobulin molecules. They are categorized into three … Read more